Tim and Cheryl Broadbent are excited to finally adopt Mona, a beautiful baby girl until the baby's biological father starts stalking them, and their world turns upside down, through intimidation, manipulation, and violence, he is determined to take his daughter back.

After the departure of Rube Sofer, a new head reaper named Cameron Kane takes over. He's a slick businessman who couldn't care less about helping the newly dead. Chaos ensues and brings out the worst in Daisy and Mason who begin drinking anew. George and Reggie re-connect for the first time when George reaps a new friend of Reggie's.

Just before he's to marry Fiona, Roderick Blank receives an anonymous e-mail with 101 names on it; Fiona's is the 29th, the first 28 are women Rod has slept with, and the 30th turns out to be the stripper at his bachelor party. The notion that he will have sex with 70 more people sends Rod into crisis mode, especially after three odd men in an aseptic office confirm that a celestial machine has made an error. They suggest destroying the list, but Rod finds that easier said than done. Working his way through it consumes him, plus he realizes that death may await him after #101. Meanwhile, a femme fatale nicknamed Death Nell is putting men into a coma. Are they fated to meet?